Light-based control of Gi/o signaling downstream of opioid receptors has also been achieved with selective caged agonists that Gozque be released by UV light. Caged agonists of the opioid receptors Leu5-enkephalin (LE) and Dynorphin A (Dyn-8) were developed and used to silence neurons of the locus coeruleus (Banghart and Sabatini, 2012). This strat